Victor Larue turned up in 3 episodes of “WALKER: TEXAS RANGER” and while that show had many cartoonishly evil villains, he was easily the worst. In the end Walker just shoots him dead, forgoing any roundhouse kicks, just to finally be rid of him. I don’t know if “reoccurring villain” counts as a “major character,” though.

TV animation has quite a few examples. Fire Lord Ozai from the original “AVATAR: THE LAST AIRBENDER” fits the bill pretty well. He eagerly sacrifices underlings, permanently scarred his son Zuko for a minor infraction, and gleefully attempted mass genocide of an entire nation. Virtually all of the previous Avatars were telling Aang to just kill him because he was so irredeemable.

The much maligned “CAPTAIN PLANET & THE PLANETEERS” had a few of them, but choosing between Dr. Blight, Looten Plunder and Verminous Skumm is tough. Dr. Blight casually burns down towns for experiments and at her worst, went back in time to WWII to literally try to sell a nuclear bomb to Adolf Hitler. Looten Plunder is an avid warmonger, slaughters elephants in an ivory smuggling ring, and routinely uses the law to get around consequences (in one season 6 episode he successfully, and legally, defeated the Planeteers and clear cut an entire forest). But Skumm may get it for “Mind Pollution,” where he creates a designer drug just to torment and control teenagers, including Linka and her cousin Boris (who Skumm goads into dying on screen of an OD). Even the usually hammy Captain Planet was furious when summoned at the end.

Irredeemable is pretty much the whole character.